An antidote exists for Tetrodotoxin and Saxitoxin.

• A. True
• B. Some antidote exists
• C. False
• D. Not known

Answer: (C)

Tetrodotoxin and saxitoxin work by blocking voltage-gated sodium channels, which stops nerve impulses and can lead to numbness, paralysis, and potentially complete respiratory failure. Because there isn’t a proven, clinically available antidote that reverses this blockade in humans, there is no specific antidote for either toxin. Treatment relies on rapid, supportive care: securing the airway and providing ventilatory support as needed, monitoring and supporting cardiovascular function, and decontamination if exposure was recent (for example, using activated charcoal within a short window after ingestion). Experimental approaches have been studied, but none are established standard antidotes. So the statement that an antidote exists is not correct.